Ovarian Cysts Research Today is a free monthly online journal that collates and summarizes the latest research about Ovarian Cysts, including details on causes, treatment, symptoms, infertility.

Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria.

Shroff R, Syrop CH, Davis W, Van Voorhis BJ, Dokras A

Department of Obstetrics and Gynecology, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.

OBJECTIVE: To determine the risk of metabolic complications, primarily metabolic syndrome, in all polycystic ovary syndrome (PCOS) phenotypes compared with control subjects. DESIGN: Retrospective chart review. SETTING: University practice. PATIENT(S): Women with PCOS (Rotterdam definition; n = 258) and women without PCOS seen during the same time period for an annual exam used as controls (n = 110). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Metabolic syndrome. RESULT(S): Three PCOS phenotypes had a significantly higher prevalence of metabolic syndrome compared with the control subjects: oligomenorrhea/oligo-ovulation (O) + hyperandrogenism (H) + polycystic ovaries (P), age-adjusted odds ratio [OR] 6.3 (95% confidence interval 2.1-18.9); O+H, OR 7.8 (2.2-27.5); and H+P, OR 8.2 (2.3-29.3). There was no significant difference in the prevalence of metabolic syndrome between women with O+P and control subjects, even in obese women. The prevalence of insulin resistance and glucose intolerance was not significantly different between POCS phenotypes CONCLUSION(S): The risk of metabolic syndrome may vary among the four phenotypes of PCOS based on the Rotterdam criteria. This new information may be of relevance in counseling women with PCOS although larger studies may be needed to validate our findings.

Published 9 November 2007 in Fertil Steril, 88(5): 1389-95.
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