Ovarian Cysts Research Today is a free monthly online journal that collates and summarizes the latest research about Ovarian Cysts, including details on causes, treatment, symptoms, infertility.

Ovarian enzyme activities in women with polycystic ovary syndrome.

Magoffin DA

Department of Obstetrics and Gynecology, Cedars-Sinai Burns and Allen Research Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA. magoffin@cshs.org

Studies using primary ovarian tissue and cultured human theca and granulosa cells have shown that steroidogenic enzyme activities are up-regulated in theca cells in polycystic ovary syndrome (PCOS). Although granulosa cells in arrested follicles in PCOS fail to express significant amounts of aromatase, there is an overexpression of 5alpha-reductase activity and premature expression of cholesterol side-chain cleavage cytochrome P450.

Published 26 June 2006 in Fertil Steril, 86: S9-S11.
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